GHK-CU 100mg
Janoshik
Batch GHKC-CA-26F-100
GHK-Cu
Copper Peptide Research Compound
GHK-Cu is a copper-binding peptide widely examined for its role in cellular repair signaling and tissue remodeling processes in laboratory studies. Research often focuses on its influence on collagen-related activity, skin-associated pathways, and overall regenerative mechanisms within controlled experimental settings.
This product is intended strictly for laboratory research use within the United States. It is not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable U.S. federal, state, and local regulations.
GHK-Cu is a synthetic copper-binding tripeptide composed of glycine, histidine, and lysine complexed with copper ions. It is developed for controlled laboratory research involving peptide–metal interaction systems.
In scientific literature, GHK-Cu is studied in experimental models examining extracellular matrix signaling pathways, cellular communication frameworks, and tissue-related regulatory mechanisms under in vitro and preclinical research conditions.
Third-party tested for purity, identity, quantity.
GHK-Cu was first identified in the 1970s as a naturally occurring copper-binding peptide. Research has examined its interaction with extracellular matrix components, metalloproteinase signaling systems, and cellular regulatory pathways within controlled laboratory environments.
Experimental studies evaluate peptide–metal complex dynamics and pathway-level signaling frameworks under in vitro and preclinical research conditions.
The tripeptide GHK was originally isolated from human plasma and later identified as a copper-binding complex. Early investigations explored its biochemical properties and signaling interactions, leading to expanded research into extracellular matrix regulation and peptide-mediated cellular communication.
Over time, GHK-Cu became a widely studied peptide–metal complex within structural and signaling research models.
Laboratory investigations into GHK-Cu have focused on extracellular matrix interaction models, metalloproteinase-related pathways, and peptide–metal complex signaling systems. Research frameworks evaluate copper-binding dynamics and cellular regulatory mechanisms under controlled in vitro and preclinical conditions.
2 of the 4 areas below are addressed directly by a paper cited on this page.
Extracellular matrix signaling models
No paper cited on this page reports on extracellular or matrix. This heading marks where GHK-Cu is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Metalloproteinase pathway research
No paper cited on this page reports on metalloproteinase. This heading marks where GHK-Cu is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Peptide–metal complex interaction studies
Addressed on this page by Maquart 1988, Maquart 1993, Pickart 2015. The work appeared in J Clin Invest. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Maquart, F.X. et al. (1988) — Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.
- Maquart, F.X. et al. (1993) — In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds. J Clin Invest 92(5):2368–2376.
- Pickart, L. et al. (2015) — GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
Cellular communication framework investigations
Addressed on this page by Pickart 2015. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Pickart, L. et al. (2015) — GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
The references section of this page cites 3 primary papers published between 1988 and 2015 — a thin record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for GHK-Cu, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
GHK-Cu is also referred to as copper peptide, GHK, blue copper.
Described as a collagen-stimulating and skin-regenerating peptide.
GHK-Cu is a copper-binding tripeptide first isolated from human plasma, and the published research examines its role in collagen synthesis, matrix remodelling and wound-healing models — largely in cell culture and animal studies, with some work on topical cosmetic formulations. Loren Pickart, who first characterised it, is the author of much of the foundational work. Results from topical cosmetic studies do not transfer to other contexts.
Described as broadly beneficial across skin, hair, lung and neurological conditions.
The breadth of that claim comes largely from gene-expression studies reporting that GHK modulates the expression of a very large number of human genes. Broad transcriptional effects in cell culture are a hypothesis-generating finding, not evidence of clinical benefit in any one of those areas, and the individual indications have not been tested in controlled human trials.
Described as safe because copper is an essential trace element.
Copper being essential in trace amounts says nothing about the safety of a copper-carrying peptide delivered in a research context. Copper homeostasis is tightly regulated and copper overload is itself a recognised toxicity. No human clinical safety data has been published for GHK-Cu outside topical cosmetic use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Verification for GHK-Cu is per lot, not per product. The current 100mg lot GHKC-CA-26F-100 returned 99.848% purity, 111.26 mg measured, 111.3% of the labelled 100 mg, assayed by Janoshik. Those figures are the laboratory's, published in full rather than reduced to a badge.
Purity is half the number. It states what fraction of the material in the vial is GHK-Cu; it says nothing about how much material is in the vial, and a short-filled vial can return a purity result that is entirely accurate. The figure that answers the second question is measured mass against expected content — for GHK-Cu, this lot measured 111.3% of its labelled 100 mg. Both numbers are published for every lot, whichever way they fall.
The lot code printed on the vial matches the code on the certificate for GHK-Cu. Matching the two is what confirms the unit in hand came from the batch that was tested — a certificate not tied to a lot code proves nothing about any particular unit.
Researchers who buy GHK-Cu in the United States through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.
- Lyophilized storage
- −20 °C long-term; stable at room temperature in transit
- After reconstitution
- 2–8 °C
- Light
- Protect from UV and direct light
- Freeze-thaw
- Avoid repeated cycles
- Vehicle
- Bacteriostatic water in most published protocols
- Format
- Lyophilized powder
GHK-Cu is supplied as lyophilized powder. In the dry state the material is comparatively stable, which is why it ships at ambient temperature without a cold chain; once reconstituted it is a peptide in solution and the handling constraints tighten considerably. At 3 residues it is short enough to be produced by solid-phase synthesis, and the published sequence on this page is what an identity assay is checked against.
Repeated freeze-thaw cycling is the handling error most likely to degrade material of this class, because each cycle concentrates solutes at the ice boundary. Where a protocol calls for the same vial across multiple sessions, the published literature generally describes aliquoting after reconstitution rather than re-freezing the whole volume.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
- 1 × sealed glass vial in the strength selected (100mg / Single Vial, 50mg / Single Vial, 100mg / 5-Pack, 100mg / 10-Pack, 50mg / 5-Pack, 50mg / 10-Pack available), batch-labelled
- The batch-linked Certificate of Analysis for the exact lot shipped
- Discreet outer packaging with no product names on the exterior
- FedEx, tracked, typically 1–3 business days domestically
- Bacteriostatic water or any other reconstitution vehicle
- Syringes, needles or filters
- Dosing, administration or protocol guidance of any kind
Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each vial contains 120mg of lyophilized GHK-Cu. Independent third-party testing verifies purity, identity, and net content per batch.
The vial contains only the peptide preparation. Any laboratory materials required for experimental procedures must be sourced separately.
Duration depends entirely on research protocol, storage conditions, and laboratory application.
Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+.
PubMedIn vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds. J Clin Invest 92(5):2368–2376.
PubMedGHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration.
PubMedRelated
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