

Livagen 20mg
Janoshik
Batch LIVE-CA-26F-20
Livagen
Peptide Bioregulator
Also known as Lys-Glu-Asp-Ala (KEDA)
Livagen is the tetrapeptide Lys-Glu-Asp-Ala, studied in research on hepatic tissue models and on chromatin activation in lymphocytes.
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This product is intended strictly for laboratory research use within the United States. It is not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable U.S. federal, state, and local regulations.
Livagen is the tetrapeptide Lys-Glu-Asp-Ala, studied in research on hepatic tissue models and on chromatin activation in lymphocytes.
Experimental work examines tissue-specific short-peptide activity in cultures from animals and donors of different ages.
Livagen is among the better-documented short peptide bioregulators. Published studies have examined chromatin decondensation in lymphocytes from older donors, protein-synthesis rhythms in hepatocyte cultures, and digestive-enzyme activity in rodent models.
That work sits within a broader research model in which short peptides are proposed to act on heterochromatin and gene expression rather than through classical receptor pharmacology.
Livagen was characterized as one of a series of tissue-directed tetrapeptides in the Russian peptide-bioregulator programme, with an emphasis on hepatic tissue.
Subsequent research extended into lymphocyte chromatin studies, which became some of the most cited work in this compound class.
Research into Livagen focuses on chromatin activation in ageing lymphocytes and on tissue-specific effects in hepatic culture models. Frameworks evaluate heterochromatin decondensation, protein-synthesis rhythms, and enzyme activity under controlled in vitro and preclinical conditions.
3 of the 4 areas below are addressed directly by a paper cited on this page.
Lymphocyte chromatin activation models
Addressed on this page by Khavinson 2002, Khavinson 2004. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Khavinson, VKh. et al. (2002) — Effects of Livagen peptide on chromatin activation in lymphocytes from old people
- Khavinson, VKh. et al. (2004) — Effects of short peptides on lymphocyte chromatin in senile subjects
Hepatic tissue-culture research
Addressed on this page by Brodskiĭ 2001. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Brodskiĭ, VIa. et al. (2001) — Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen
Tissue-specific short-peptide activity
Addressed on this page by Khavinson 2004, Khavinson 2002, Brodskiĭ 2001. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Khavinson, VKh. et al. (2004) — Effects of short peptides on lymphocyte chromatin in senile subjects
- Khavinson, VKh. et al. (2002) — Effects of Livagen peptide on chromatin activation in lymphocytes from old people
- Brodskiĭ, VIa. et al. (2001) — Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen
Cellular ageing and gene-expression studies
No paper cited on this page reports on cellular, ageing or gene. This heading marks where Livagen is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
The references section of this page cites 4 primary papers published between 2001 and 2005 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Worth noting when weighing that record: roughly 50% of the citations here list Khavinson as lead author. A literature concentrated in one research group has not been independently replicated to the same degree as one drawn from many, and that is a real limitation on how far the findings can be generalised — regardless of how consistent the individual results look.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Livagen, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Livagen is commonly described online in connection with faster healing from injury and improved recovery. In the research literature the same compound is filed under lymphocyte chromatin activation models, hepatic tissue-culture research and tissue-specific short-peptide activity.
The 4 papers cited on this page, published between 2001 and 2005 (2 in animal models) describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Presented as having independent scientific backing.
Around 50% of the papers cited here list Khavinson as lead author. A literature concentrated in one research group has not been independently replicated to the degree its volume suggests, and that is a real limit on how far the findings generalise — however consistent the individual results appear.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Verification for Livagen is per lot, not per product. The current 20mg lot LIVE-CA-26F-20 returned 99.917% purity, 24.39 mg measured, 122% of the labelled 20 mg, assayed by Janoshik. Those figures are the laboratory's, published in full rather than reduced to a badge.
Purity is half the number. It states what fraction of the material in the vial is Livagen; it says nothing about how much material is in the vial, and a short-filled vial can return a purity result that is entirely accurate. The figure that answers the second question is measured mass against expected content — for Livagen, this lot measured 122% of its labelled 20 mg. Both numbers are published for every lot, whichever way they fall.
The lot code printed on the vial matches the code on the certificate for Livagen. Matching the two is what confirms the unit in hand came from the batch that was tested — a certificate not tied to a lot code proves nothing about any particular unit.
Researchers who buy Livagen in the United States through Eppix Labs receive the lot described by the certificate above: the code printed on the vial label is the code on the certificate, and both are searchable on the batch verification page.
- Lyophilized storage
- −20 °C long-term; stable at room temperature in transit
- After reconstitution
- 2–8 °C
- Light
- Protect from UV and direct light
- Freeze-thaw
- Avoid repeated cycles
- Vehicle
- Bacteriostatic water in most published protocols
- Format
- Lyophilized powder
Livagen is supplied as lyophilized powder. In the dry state the material is comparatively stable, which is why it ships at ambient temperature without a cold chain; once reconstituted it is a peptide in solution and the handling constraints tighten considerably. At 4 residues it is short enough to be produced by solid-phase synthesis, and the published sequence on this page is what an identity assay is checked against.
Repeated freeze-thaw cycling is the handling error most likely to degrade material of this class, because each cycle concentrates solutes at the ice boundary. Where a protocol calls for the same vial across multiple sessions, the published literature generally describes aliquoting after reconstitution rather than re-freezing the whole volume.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
- 1 × sealed glass vial in the strength selected (20mg / Single Vial, 20mg / 5-Pack, 20mg / 10-Pack available), batch-labelled
- The batch-linked Certificate of Analysis for the exact lot shipped
- Discreet outer packaging with no product names on the exterior
- FedEx, tracked, typically 1–3 business days domestically
- Bacteriostatic water or any other reconstitution vehicle
- Syringes, needles or filters
- Dosing, administration or protocol guidance of any kind
Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each unit contains the labeled quantity of Livagen. Independent third-party analysis verifies purity, identity, and net content per batch.
The unit contains only the research compound. Any laboratory materials required for reconstitution or experimental procedures must be sourced separately.
Duration depends entirely on research design, storage conditions, and laboratory protocol.
Effects of Livagen peptide on chromatin activation in lymphocytes from old people
PubMedEffects of short peptides on lymphocyte chromatin in senile subjects
PubMedRhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen
PubMedEffect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages
PubMedRelated
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