Humanin
Mitochondrial-Derived Peptide
Also known as HN, 24-residue mitochondrial ORF peptide
Humanin is a 24-residue peptide encoded within the mitochondrial genome, studied in research on cytoprotection and apoptosis-related signaling.
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This product is intended strictly for laboratory research use within the United States. It is not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable U.S. federal, state, and local regulations.
Humanin is a 24-residue peptide encoded within the mitochondrial genome, studied in research on cytoprotection and apoptosis-related signaling.
Experimental models examine its release from mitochondria and its influence on stress-resistance pathways.
Third-party tested for purity, ID, quantity.
Coming Soon
The certificate of analysis for the 10mg lot is being finalised and will be published here as soon as the lab returns it.
Humanin was the first mitochondrial-derived peptide to be described, transcribed from a short open reading frame in the mitochondrial 16S rRNA region. Research has characterized its cytoprotective activity, including suppression of apoptosis and modulation of stress-response signaling in neuronal, cardiac, and metabolic models.
Studies have examined its release by astrocytes, its relationship to lifespan and healthspan endpoints, and its behaviour within the wider mitokine literature alongside MOTS-c.
Humanin was identified in screening work seeking factors that protect neurons from amyloid-beta toxicity, and was subsequently traced to a mitochondrial open reading frame.
That discovery opened the mitochondrial-derived peptide field, with later work characterizing humanin across cardiovascular, reproductive, oncological, and ageing research models.
Research into humanin focuses on mitochondrial-derived peptide signaling and cytoprotection. Frameworks evaluate apoptosis suppression, stress-resistance pathways, synaptic maintenance, and lifespan-related endpoints under controlled in vitro and preclinical conditions.
3 of the 4 areas below are addressed directly by a paper cited on this page.
Mitochondrial-derived peptide (mitokine) signaling
Addressed on this page by Hazafa 2021, Yen 2013, Zárate 2019. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Hazafa, A. et al. (2021) — Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
- Yen, K. et al. (2013) — The emerging role of the mitochondrial-derived peptide humanin in stress resistance
- Zárate, SC. et al. (2019) — Humanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons
Apoptosis and cytoprotection models
Addressed on this page by Hazafa 2021. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Hazafa, A. et al. (2021) — Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
Neuroprotection and synaptic maintenance research
No paper cited on this page reports on neuroprotection, synaptic or maintenance. This heading marks where Humanin is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Ageing, lifespan, and healthspan endpoint studies
Addressed on this page by Yen 2020. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Yen, K. et al. (2020) — The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
The references section of this page cites 5 primary papers published between 2013 and 2021 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Humanin, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Humanin is also referred to as HN, and technically as HN, 24-residue mitochondrial ORF peptide.
Humanin is commonly described online in connection with weight loss, appetite suppression and fat reduction. In the research literature the same compound is filed under mitochondrial-derived peptide (mitokine) signaling, apoptosis and cytoprotection models and neuroprotection and synaptic maintenance research.
The 5 papers cited on this page, published between 2013 and 2021 describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Every lot of Humanin is independently assayed before it is released, and the certificate for the lot shipped is published rather than summarised. Where a certificate for a current lot is not yet posted, the lot has not yet been released against it.
Researchers who buy Humanin in the United States through Eppix Labs receive a batch-labelled vial whose certificate is published against that lot code, so the material can be matched to its analysis rather than to a generic specification.
- Lyophilized storage
- −20 °C long-term; stable at room temperature in transit
- After reconstitution
- 2–8 °C
- Light
- Protect from UV and direct light
- Freeze-thaw
- Avoid repeated cycles
- Vehicle
- Bacteriostatic water in most published protocols
- Format
- Lyophilized powder
Humanin is supplied as lyophilized powder. In the dry state the material is comparatively stable, which is why it ships at ambient temperature without a cold chain; once reconstituted it is a peptide in solution and the handling constraints tighten considerably. At 24 residues it is short enough to be produced by solid-phase synthesis, and the published sequence on this page is what an identity assay is checked against.
Repeated freeze-thaw cycling is the handling error most likely to degrade material of this class, because each cycle concentrates solutes at the ice boundary. Where a protocol calls for the same vial across multiple sessions, the published literature generally describes aliquoting after reconstitution rather than re-freezing the whole volume.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
- 1 × sealed glass vial in the strength selected (10mg / Single Vial, 10mg / 5-Pack, 10mg / 10-Pack available), batch-labelled
- Batch documentation for the lot shipped, once its certificate is published
- Discreet outer packaging with no product names on the exterior
- FedEx, tracked, typically 1–3 business days domestically
- Bacteriostatic water or any other reconstitution vehicle
- Syringes, needles or filters
- Dosing, administration or protocol guidance of any kind
Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each unit contains the labeled quantity of humanin. Independent third-party analysis verifies purity, identity, and net content per batch.
The unit contains only the research compound. Any laboratory materials required for reconstitution or experimental procedures must be sourced separately.
Duration depends entirely on research design, storage conditions, and laboratory protocol.
Humanin: A mitochondrial-derived peptide in the treatment of apoptosis-related diseases
PubMedThe emerging role of the mitochondrial-derived peptide humanin in stress resistance
PubMedHumanin, a Mitochondrial-Derived Peptide Released by Astrocytes, Prevents Synapse Loss in Hippocampal Neurons
PubMedThe mitochondrial derived peptide humanin is a regulator of lifespan and healthspan
PubMedMitochondrial-derived peptide humanin as therapeutic target in cancer and degenerative diseases
PubMedRelated
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