Epitalon Capsules
Epitalon Capsules USA — Capsules
Synthetic Pineal Tetrapeptide
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly, also written AEDG) modelled on peptide fractions isolated from pineal tissue. It is supplied in capsule form strictly for laboratory research and is handled within controlled experimental settings.
This product is intended strictly for laboratory research use within the United States. It is not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable U.S. federal, state, and local regulations.
Epitalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly, also written AEDG) modelled on peptide fractions isolated from pineal tissue. It is supplied in capsule form strictly for laboratory research and is handled within controlled experimental settings.
In scientific literature, epitalon has been examined in relation to telomerase activity, telomere length in cultured human cells, pineal secretory activity in rodents, gene expression during neurogenesis, and oocyte and retinal cell models.
Third-party tested for purity, ID, quantity.
Coming Soon
The certificate of analysis for this lot is being finalised and will be published here as soon as the lab returns it.
Epitalon is described in the literature as a short peptide regulator derived from work on pineal peptide extracts. Reported mechanisms under investigation include upregulation of telomerase expression and, in some cell lines, alternative lengthening of telomeres, along with proposed epigenetic interaction with gene promoter regions associated with transcription and protein synthesis. Published reviews characterise it as a bioactive tetrapeptide with antioxidant properties examined in cell and animal systems.
Research endpoints evaluated include telomere length and telomerase activity in human cell lines, oxidative and morphological damage in post-ovulatory mouse oocytes in vitro, maturation rate and post-thaw embryo development in bovine oocytes, wound closure in an in vitro model of diabetic retinopathy, pineal secretory output in stress-exposed rats, neocortical neuron activity in rats, proliferative activity and apoptosis in rat colon tumour and mucosal tissue, spontaneous tumour incidence in mice, and lifespan measurements in Drosophila melanogaster.
Epitalon emerged from Russian gerontological peptide research, where fractions obtained from pineal tissue were characterised and short synthetic sequences were produced to reproduce the observed activity. Early published work from this programme placed the peptide within a broader framework of peptide bioregulators and ageing, including lifespan studies in Drosophila and studies of pineal secretion in rats.
Subsequent publications extended the record into rodent carcinogenesis models, neuronal activity measurements, and neurogenesis-related gene expression. More recent work, published from 2022 onward, has concentrated on cell culture systems: telomere and telomerase measurements in human cell lines, oocyte models in mouse and bovine systems, and retinal cell wound healing models. Much of the earlier literature originates from a small number of affiliated research groups, and the record remains predominantly preclinical.
Laboratory investigations into epitalon appear mainly within gerontology and cellular senescence frameworks, with telomerase activity and telomere length as recurring measured endpoints in human cell lines. Additional research frameworks include reproductive cell biology, where mouse and bovine oocyte models have been used to assess maturation and post-ovulatory changes in vitro; ocular cell models examining wound closure under hyperglycaemic conditions; rodent neuroendocrine studies measuring pineal secretory activity and neocortical neuron activity; and rodent carcinogenesis models assessing proliferation and apoptosis. Lifespan data exist in an invertebrate model. Human clinical evidence is limited, and the compound is studied here only under in vitro and preclinical conditions.
3 of the 5 areas below are addressed directly by a paper cited on this page.
Telomerase and telomere length models
Addressed on this page by Al-Dulaimi 2025, Ullah 2025. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Al-Dulaimi, S. et al. (2025) — Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
- Ullah, S. et al. (2025) — Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
Cellular senescence and gerontology research
No paper cited on this page reports on cellular, senescence or gerontology. This heading marks where Epitalon Capsules is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
Oocyte maturation and embryo development models
Addressed on this page by Ullah 2025, Yue 2022. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Ullah, S. et al. (2025) — Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
- Yue, X. et al. (2022) — Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
Pineal and neuroendocrine signaling studies
Addressed on this page by Araj 2025. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Araj, SK. et al. (2025) — Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
Rodent carcinogenesis models
No paper cited on this page reports on rodent or carcinogenesis. This heading marks where Epitalon Capsules is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
The references section of this page cites 6 primary papers published between 2020 and 2025 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Epitalon Capsules is frequently listed as a peptide by suppliers in this market. It is not one. The structure published on this page is the compound's actual chemistry, and research on it should be read against its own class rather than against peptide literature.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Epitalon Capsules, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Epitalon Capsules is commonly described online in connection with faster healing from injury and improved recovery. In the research literature the same compound is filed under telomerase and telomere length models, cellular senescence and gerontology research and oocyte maturation and embryo development models.
The 6 papers cited on this page, published between 2020 and 2025 (1 in animal models and 1 review) describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Every lot of Epitalon Capsules is independently assayed before it is released, and the certificate for the lot shipped is published rather than summarised. Where a certificate for a current lot is not yet posted, the lot has not yet been released against it.
Researchers who buy Epitalon Capsules in the United States through Eppix Labs receive a batch-labelled vial whose certificate is published against that lot code, so the material can be matched to its analysis rather than to a generic specification.
- Storage
- Cool, dry, away from direct light
- Humidity
- Keep sealed; capsule shells are hygroscopic
- Reconstitution
- Not applicable — supplied pre-measured
- Format
- Oral capsule
Epitalon Capsules is supplied in capsule form, which removes the reconstitution step entirely: there is no vehicle to add, no reconstitution volume to record and no post-reconstitution stability window to track. What that leaves a laboratory to control is storage — capsule shells draw moisture from the air, so the container should be kept sealed and dry rather than decanted into an open vessel.
Because the material is already at its labelled quantity per capsule, batch verification carries more weight in this format than it does for powder: there is no point at which the researcher independently confirms mass by weighing. The measured content published for each lot is the figure that answers that question.
- 1 × sealed capsule bottle (3mg per capsule / Single Bottle - Pack of 60), batch-labelled
- Batch documentation for the lot shipped, once its certificate is published
- Discreet outer packaging with no product names on the exterior
- FedEx, tracked, typically 1–3 business days domestically
- Laboratory consumables of any kind
- Dosing, administration or protocol guidance of any kind
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each capsule contains the labeled quantity of epitalon, and each bottle contains the labeled capsule count. Independent third-party analysis verifies purity, identity, and net content per batch.
The capsules contain only the compound and standard encapsulation excipients. Any laboratory materials required for extraction, preparation, or experimental procedures must be sourced separately.
Duration depends entirely on research design, storage conditions, and laboratory protocol.
Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity
PubMedOverview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties
PubMedAEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism
PubMedEpitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro
PubMedEpitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development
PubMedThe Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy
PubMedRelated
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