Vilon
Peptide Bioregulator
Also known as Lys-Glu (KE)
Vilon is the dipeptide Lys-Glu, one of the most extensively studied short peptide bioregulators, examined in research on chromatin activation and immune endpoints.
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This product is intended strictly for laboratory research use within the United States. It is not approved by the FDA for the diagnosis, treatment, cure, or prevention of any disease. Not for human or veterinary use.
By purchasing, you confirm the material will be used solely for lawful research purposes in accordance with applicable U.S. federal, state, and local regulations.
Vilon is the dipeptide Lys-Glu, one of the most extensively studied short peptide bioregulators, examined in research on chromatin activation and immune endpoints.
Experimental models span lymphocyte cultures from older donors, gene-expression profiling, and tumour-induction studies in rodents.
Third-party tested for purity, ID, quantity.
Coming Soon
The certificate of analysis for the 20mg lot is being finalised and will be published here as soon as the lab returns it.
Vilon is a two-residue peptide with an unusually broad literature for its size. Published work has reported reactivation of chromatin in cultured lymphocytes from older people, effects on gene expression in mouse heart characterized by DNA microarray, and modulation of gene expression in ageing mesenchymal stem cell cultures.
Separate research examined signal transduction along the sphingomyelin pathway in thymocytes, and the peptide appears throughout reviews of short-peptide epigenetic regulation.
Vilon was among the first synthetic short peptides characterized in the Russian bioregulator programme, developed as a defined analogue of thymic peptide preparations.
Work from the late 1990s onward established it as the reference compound for the class, frequently used as a comparator against Epitalon.
Research into the Lys-Glu dipeptide focuses on chromatin reactivation in ageing cells and on gene-expression regulation. Frameworks evaluate heterochromatin decondensation, microarray transcriptional profiles, sphingomyelin-pathway signaling, and immune endpoints under controlled in vitro and preclinical conditions.
3 of the 4 areas below are addressed directly by a paper cited on this page.
Chromatin reactivation in ageing lymphocytes
Addressed on this page by Lezhava 2004. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Lezhava, T. et al. (2004) — Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people
Microarray gene-expression profiling
Addressed on this page by Anisimov 2002, Ashapkin 2020. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Anisimov, SV. et al. (2002) — Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology
- Ashapkin, V. et al. (2020) — Gene expression in human mesenchymal stem cell aging cultures: modulation by short peptides
Sphingomyelin-pathway signal transduction
Addressed on this page by Khavinson 2002. Each is linked to its source record in the references below, so what was measured — and in what system — can be read rather than taken on trust.
- Khavinson, VKh. et al. (2002) — Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway
Immune and gerontology endpoint research
No paper cited on this page reports on immune, gerontology or endpoint. This heading marks where Vilon is discussed in the category rather than a question the cited literature answers, and it is worth knowing which of these areas has work behind it and which does not.
The references section of this page cites 5 primary papers published between 2002 and 2020 — a limited but non-trivial record. Every citation is linked to its PubMed or DOI record so it can be read rather than taken on trust, and the summaries above describe what those papers report rather than what the compound is claimed to do.
Research compounds attract claims that outrun their evidence. Below are the ones most often encountered for Vilon, set against what the papers cited on this page actually report. Where the record is thin or contested, that is stated rather than smoothed over.
Vilon is commonly described online in connection with slowing ageing and extending lifespan. In the research literature the same compound is filed under chromatin reactivation in ageing lymphocytes, microarray gene-expression profiling and sphingomyelin-pathway signal transduction.
The 5 papers cited on this page, published between 2002 and 2020 (1 in animal models) describe laboratory and animal work. None reports a controlled trial in humans. Findings in cell culture or in a rodent model describe what happened in that system; they do not establish that the same occurs in humans, and this compound is not approved for human use.
Nothing above is a statement of what this material does. It is a summary of what has been published and what has not. Eppix Labs supplies research materials only and provides no dosing, administration or protocol guidance.
Every lot of Vilon is independently assayed before it is released, and the certificate for the lot shipped is published rather than summarised. Where a certificate for a current lot is not yet posted, the lot has not yet been released against it.
Researchers who buy Vilon in the United States through Eppix Labs receive a batch-labelled vial whose certificate is published against that lot code, so the material can be matched to its analysis rather than to a generic specification.
- Lyophilized storage
- −20 °C long-term; stable at room temperature in transit
- After reconstitution
- 2–8 °C
- Light
- Protect from UV and direct light
- Freeze-thaw
- Avoid repeated cycles
- Vehicle
- Bacteriostatic water in most published protocols
- Format
- Lyophilized powder
Vilon is supplied as lyophilized powder. In the dry state the material is comparatively stable, which is why it ships at ambient temperature without a cold chain; once reconstituted it is a peptide in solution and the handling constraints tighten considerably. At 2 residues it is short enough to be produced by solid-phase synthesis, and the published sequence on this page is what an identity assay is checked against.
Repeated freeze-thaw cycling is the handling error most likely to degrade material of this class, because each cycle concentrates solutes at the ice boundary. Where a protocol calls for the same vial across multiple sessions, the published literature generally describes aliquoting after reconstitution rather than re-freezing the whole volume.
Vials may appear empty on arrival. Lyophilized material collects at the base of the vial and is often not visible until the vial is inspected under direct light.
- 1 × sealed glass vial in the strength selected (20mg / Single Vial, 20mg / 5-Pack, 20mg / 10-Pack available), batch-labelled
- Batch documentation for the lot shipped, once its certificate is published
- Discreet outer packaging with no product names on the exterior
- FedEx, tracked, typically 1–3 business days domestically
- Bacteriostatic water or any other reconstitution vehicle
- Syringes, needles or filters
- Dosing, administration or protocol guidance of any kind
Reconstitution materials are sourced separately. The reconstitution calculator on this site works out concentrations for a given volume, but it is an arithmetic tool for laboratory record-keeping and not a protocol.
No. Eppix Labs products are supplied exclusively for laboratory research. We do not provide dosing, administration, or usage guidance.
Each unit contains the labeled quantity of Vilon. Independent third-party analysis verifies purity, identity, and net content per batch.
The unit contains only the research compound. Any laboratory materials required for reconstitution or experimental procedures must be sourced separately.
Duration depends entirely on research design, storage conditions, and laboratory protocol.
Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people
PubMedStudies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology
PubMedEffects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway
PubMedGene expression in human mesenchymal stem cell aging cultures: modulation by short peptides
PubMedRelated
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